The Landwehr Canal cuts through Berlin between Kreuzberg and Schöneberg. There are paths that allow you to run along the water, stretching from one end of the city to the other.
A good 5K and a river running route, also passing through Checkpoint Charlie and both the Modern Art Museum and the Jüdisches Museum Berlin, begins at the corner of Axel-Springer-str. and Leipziger Str. in front of Motel One, only a few minutes’ walk from the Spittelmarkt U-Bahn.
From there you run south down Axel-Springer and Lindenstr. until you reach the river. Then you can cross the canal on the other side and run along the river across the street from the Zentral- und Landesbibliothek (Library) or you can run under the train station Hallesches Tor towards Wilhelm Str. (right turn) and back up toward the Checkpoint Charlie area, passing the Willy-Brandt-Haus Cultural Center. At Leipziger Str. you turn right and stay on the path all the way back to Axel-Springer Str. and Motel One. The route finishes at just under 5K.
A few things to consider: The area can be very crowded during rush hours, as you will pass through several bus and train stations. The best time to run it is either noon, preferably after lunch hours or after 8 p.m.
On weekends Checkpoint Charlie tends to be busy, but passing through is always quick if you’re trying to keep a brisk pace and finish the route in under 30 minutes.
The route looks like this: